I don't like House because House is so sarcastic and egoistic. He's really a big douchbag (albeit a rather smart douchbag) and I can't stand them irl, so why choose to sit in front of one for 40 minutes?
It's what makes him great. He's hilarious and pwns all in sight. He's like Dr. Cox, but better. He could stare into your soul if he were real.
The first three seasons are great, and they only get better. The fourth hit a bit of a wall with cases that aren't quite as involving, mostly lacking the interaction of the original three subordinates (who are still on the show).
We all want to be able to be that much of a jerk. Because the only way we could get away with it is if we were incredibly more right than everyone else 99% of the time.
House is one of the best shows on TV; fact. Last season rocked, this season rocks, people who don't like House are evil to their very core.